NURS 6630 Week8 Assignment
Mood Stabilizer
This Assignment is designed to help you analyze the many considerations for prescribing mood stabilizers, as well as organizing the many different lab components to consider when prescribing to a patient. NURS 6630 Week8 Assignment.
The Assignment
Construct a 5- to 6-page paper discussing each of the four traditional mood stabilizer medications: carbamazepine, lamotrigine, lithium, and valproate products. Support your answers with five (5) evidence-based, peer-reviewed scholarly literature.
Note: APA style format will apply.
Your paper should include the following for each:
- Proposed mechanism of action
- Baseline assessment, laboratory considerations, and frequency of ongoing labs and assessments
Note: Discuss the importance of assessment and labs. - Special population considerations (birth assigned gender, age, other medical comorbidity considerations)
- FDA approval indications
- Typical dosing with discussion on therapeutic endpoints for psychiatric use
- Major drug–drug interaction considerations
- For each of these medications, please review potential drug–drug interactions listed below. Consider alternative dosing schedules, clinical implications for the drug interactions, additional patient education needed, any additional monitoring recommended, or collaboration needed with other medical professions (such as, primary care providers)
- Lamotrigine + Valproate
- Lamotrigine + Rifampin
- Valproate + Estrogen containing birth control.
- Valproate + Amitriptyline
- Lithium + Furosemide
- Lithium + Lisinopril
- Carbamazepine + Lurasidone
- Carbamazepine + Grapefruit juice
- Discuss the ethical, legal, and social implications related to prescribing bipolar and other related mood-disorder diagnoses therapy for patients.
- For each of these medications, please review potential drug–drug interactions listed below. Consider alternative dosing schedules, clinical implications for the drug interactions, additional patient education needed, any additional monitoring recommended, or collaboration needed with other medical professions (such as, primary care providers)
Solution: NURS 6630 Week8 Assignment
Analysis of Mood Stabilizer
Introduction
Mood stabilizers including carbamazepine, lamotrigine, lithium, and valproate are fundamental for the management of mood disorders such as bipolar disorder. The medications work by handling the neurotransmitter systems and ion channels for the reduction of neuronal excitability, prevention of manic and depressive episodes as well as the promotion of long-term stability. The drugs have specific pharmacological mechanisms, considerations for special populations, and possible drug interactions hence making patient-centered treatment for optimization of the patient outcome.
Carbamazepine
Proposed Mechanism of Action
Carbamazepine is a common medication used for the stabilization of moods by inhibiting sodium channels. The action helps in the reduction of neuronal excitability and is ideal for the prevention of mood episodes among persons suffering from bipolar disorder (Okuma, 2020). The medication as well helps in the modulation of neurotransmitter release specifically glutamate and aspartate which helps in the contributing of mood-stabilizing effects. The impact leads to a balanced mood and reduces the episodes of mania.
Baseline Assessment and Laboratory Considerations
It is important that before prescribing the medication, a healthcare provider is supposed to carry out a baseline assessment including a complete blood count and liver function tests. The evaluations are ideal for the identification of any pre-existing conditions that may affect the way the medication works. Regular monitoring of the patient is important especially liver function because carbamazepine may affect the hepatic metabolism.
Special Population Considerations
Carbamazepine calls for special consideration when prescribing the medication among certain populations such as pregnant individuals and elderly persons. Among pregnant women, the drug may affect the development of the fetus including causing neural tube defects as per Beydoun et al. (2020). Among elderly persons, there is a risk of drug interactions and alteration of the pharmacokinetics due to a reduction of renal or hepatic function. There is a need for close monitoring of the side effects and setting up the dosage for the population… (click the purchase button to get full solution for only $9)
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